Powering America’s Genesis Mission: Microsoft’s commitment to scientific discovery

Today, we’re excited to share a long-term commitment to the Department of Energy’s (DOE) Genesis Mission, backed by a $60 million investment designed to accelerate AI for science and the breakthroughs it can deliver for the country. This deepened commitment includes Microsoft’s new Scientific Partnership Advancing Research & Knowledge coordination hub and program office, otherwise known as SPARK, that is focused on facilitating collaboration and scientific discovery for the Genesis Mission.

The Genesis Mission represents an ambitious vision, bringing together DOE’s 17 National Laboratories, world-class experimental facilities, decades of irreplaceable scientific data and next-generation computing into a single, unified platform capable of transforming how science gets done. The critical goal of the Genesis Mission is to double the productivity and impact of American research and innovation within a decade by embedding AI directly into the scientific process. It’s a bold step forward and exactly the kind of moonshot that defines American science.

At Microsoft, we believe that this goal is not only achievable, but also essential as a national security imperative and an economic engine for generations to come. With this commitment and the launch of SPARK, we’re ready to partner fully in this mission and build on our collaborations across government and with academia.

Microsoft investing in AI for science

Today, Microsoft’s $60 million investment package will begin to accelerate AI for science in support of DOE and the National Laboratories. As sustained scientific impact requires more than infrastructure alone to enable lasting scientific outcomes, Microsoft’s investment package is structured in two parts:

• $40 million in Azure compute and AI credits, distributed over three years, to power the large-scale AI and scientific workloads at the heart of the mission. This gives researchers room to train, simulate and iterate at a scale that matches their ambition.
• $20 million in solution engineering enablement services. Dedicated engineering, architecture, deployment, adoption and acceleration support to turn cloud and AI capacity into operational scientific outcomes. This investment helps ensure that the Genesis Mission advances in practice and in principle.

Together, this investment reflects a simple conviction: While infrastructure opens the door, it is people, expertise and disciplined delivery that carry discoveries across the finish line. Microsoft is committing to both.

Introducing SPARK: Microsoft’s catalyst for advancing scientific partnerships

Great partnerships need more than good intentions and good technology — they need a clear way to work together. So, alongside this commitment, we are standing up a new program office and coordination hub: SPARK, or Scientific Partnership Advancing Research & Knowledge.

SPARK is the single front door and coordination hub for Genesis Mission collaboration with Microsoft. SPARK orchestrates the full breadth of what Microsoft brings to bear: program, technical, research, engineering, security, compliance, partner and field teams into one clear, consistent path from first idea to deployed science.

SPARK is built around five commitments:

• A dedicated Genesis Mission Program Management Office. This office handles intake, prioritization, a disciplined sprint-and-checkpoint cadence and a steady operational interface with DOE for alignment, reporting and sustained partnership.
• An AI for Science Center of Excellence. An integrated delivery team that moves use cases from concept to secure, compliant, scalable implementation, with enablement through office hours, hackathons and training grounded in responsible AI and reproducible research.
• Optimization of Azure credits. Ensures computing resources are directed toward the projects where they can accelerate science most.
• Management of technical services. Dedicated support to help labs adopt and operationalize AI-for-science capabilities, delivered by Microsoft teams and select partners.
• Joint research and development. A focused set of Genesis Mission-aligned challenge problems, co-developed by Microsoft researchers and DOE scientific leadership, with milestones, publications and IP governed by mutually agreed terms.

Underneath SPARK sits the full breadth of Microsoft’s secure, FedRAMP-authorized cloud and AI portfolio. This includes Microsoft Azure infrastructure, Microsoft Foundry and Zero Trust security through Microsoft Defender, Sentinel and Entra. Azure capabilities will help extend the DOE’s American Science Cloud capabilities by providing computing, AI, data and collaboration services that complement existing scientific infrastructure. Together, these capabilities will help accelerate discovery, enable secure collaboration across institutions and provide researchers with flexible access to advanced technologies and resources. This will enable DOE and National Laboratory scientists to move faster from hypothesis to discovery, without compromising the security, reproducibility and governance that mission-critical research demands.

Accelerating science with Microsoft Discovery and Quantum

Microsoft’s new commitments build on capabilities we recently announced through Microsoft Discovery and Microsoft Quantum. They are designed to accelerate scientific research and will support the Genesis Mission’s ambition to bring AI, advanced computing and emerging technologies more deeply into the scientific process.

To enable a unified research platform for Genesis Mission work, Microsoft will provide access to Microsoft Discovery, our integrated platform that unites AI models, simulation, data and experimental workflows driven by advanced cognition rooted in scientific method, within a single governed environment. Microsoft Discovery, now generally available, includes support for autonomous lab orchestration, integration of Microsoft Research’s AI models for science, continuous AI learning through the scientific loop and agentic memory, advances in Discovery Bookshelf for data curation and scalable indexing and deeper integration and multi-hop reasoning over enterprise science data estates, including data governance. Together, these capabilities are designed to help researchers move more quickly from data to insight, from simulation to experiment, and from promising idea to scientific breakthrough.

We also recently announced the preview of the Microsoft Discovery app, a local desktop experience that helps researchers, students and scientific teams begin working with Microsoft Discovery today. Our support for the Genesis Mission will include access to the Microsoft Discovery app to enable DOE and National Laboratory teams with early access to its capabilities.

Microsoft’s recent quantum progress further strengthens the foundation for Genesis Mission work. With Majorana-based quantum advances, including more reliable topological qubits and a roadmap toward scalable quantum computing, Microsoft is helping move quantum from long-range research toward practical scientific capability. For DOE and National Laboratory teams, that progress can open new ways to model complex materials, chemistry, energy systems and national security challenges that are difficult or impossible to solve with classical computing alone. Just as important, the same agentic AI for science approach behind Microsoft Discovery is helping accelerate quantum research itself, creating a reinforcing cycle in which AI speeds quantum breakthroughs and quantum computing expands what scientists can ultimately discover.

The work is already underway

Working alongside and supporting federal researchers and universities, we’re already seeing real-world impact, from faster materials screening to advanced biosurveillance modeling. Four of the first projects taking shape under this partnership show what that looks like in practice:

Discovering critical energy storage materials and biosystems design (Pacific Northwest National Laboratory)
Using AI to dramatically accelerate the discovery of new energy storage materials through novel experimentation design and shrinking analysis of massive volumes of scientific data from years to weeks. In biosystems design, Microsoft Discovery is plugging directly into PNNL’s laboratory automation infrastructure to launch self-driving scientific workflows that autonomously design, run and fine-tune biological experiments in real time.

Strengthening biosecurity (Lawrence Livermore National Laboratory)
Pairing advanced AI with modern bioinformatics to identify emerging biological threats sooner and develop responses faster, strengthening the nation’s ability to stay ahead of the next outbreak and developing proactive defenses against evolving biosecurity risks. By applying advances in AI, scientific computing and biotechnology, Microsoft and the Lawrence Livermore National Laboratory are helping strengthen the nation’s ability to prevent, detect and respond to biological threats, advancing US biosecurity and biodefense priorities while supporting the long-term resilience and competitiveness of the US bioeconomy.

Autonomous labs for accelerated materials discovery (Johns Hopkins University Applied Physics Laboratory)
Supporting the development of AI-enabled autonomous (“self-driving”) laboratories through the integration of advanced foundation models and simulation tools — including MatterGen and MatterSim — to rapidly design, execute and optimize experiments for structural materials and superconductors. By combining autonomous experimentation with accelerated computational materials discovery, this approach dramatically shortens the path from scientific hypothesis to validated, manufacturable, mission-enabling materials, while exploring a vastly larger design space than is possible through traditional methods.

Accelerating nuclear energy permitting and autonomous energy operations (Idaho National Laboratory)
Applying AI to streamline the licensing, permitting and review of new nuclear projects. AI helps automate the development of complex engineering and safety analysis materials, a historically time-consuming and expensive process, to get this critical documentation into the hands of regulators and safety reviewers sooner. The lab also demonstrated that secure, distributed, hyperscale cloud can enable autonomous remote operations for nuclear power generators. Together, these efforts are helping bring safe and reliable power online faster and ensure scalable, efficient and reliable operations to meet the nation’s surging demand for energy.

Why this matters

We are entering an era where AI and quantum don’t just support the scientific process — they are essential to it. Through the Genesis Mission, Microsoft is committing to work as part of America’s research enterprise by providing hyperscale compute, advanced models, emerging quantum capabilities and dedicated expertise that run alongside the labs’ own world-leading systems. We are helping to ensure that the nation’s scientific strength is built on American technology. This commitment builds and expands upon the decades of collaboration through Microsoft Research and partnerships across the US government and our national labs. Now is the time to scale these breakthroughs across the entire R&D ecosystem.

The mission ahead is significant, and it should be. Whether it’s advancing the frontiers of energy, chemistry and materials science, hardening our national security or simply giving the country’s best scientists better tools to ask bigger questions, this is work worth doing and worth doing together. With a $60 million investment and SPARK, Microsoft is ready to help ensure America’s scientific leadership continues to accelerate.

Fueling scientific discovery is one of the most important things these technologies can do. AI and quantum are transforming how we tackle the toughest challenges facing the country, from sustainable materials and clean energy to biosecurity and drug discovery. The Genesis Mission is a pivotal step toward advancing that progress. We commend the DOE’s vision in building a unified, holistic approach to these critical national missions. For America to seize this opportunity and set the global standard, we must put these breakthrough technologies to work advancing the nation’s research and development.

We’re ready to deepen this partnership across government and academia. We move faster together. I’ve never been more optimistic about what’s possible when the nation’s scientific talent meets the best of modern AI and quantum. The Genesis Mission is that moment. Let’s get to work.

To get started, reach out to your Microsoft account team or email genesismission@microsoft.com.

Chris Barry leads Microsoft’s US Public Sector business. He partners with federal, state and local government and higher education agencies and organizations to accelerate digital transformation, bringing Microsoft’s secure cloud and AI capabilities to mission-critical work that serves communities across the nation.

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